If an antidepressant is not working, what can be added to make the drug work better?
1) a second antidepressant, usually from a different class
3) an atypical antipsychotic such as risperidone, olanzapine, or quetiapine
4) a type of thyroid hormone (tri-iodothyronine)
5) a stimulant
One or more of these options can be systematically tried. Before adding anything new, though, it is important to give the first drug a good chance at the highest possible dose, and for a trial of at least 2-3 months in cases of resistant depression.