tag:blogger.com,1999:blog-6886575137375451769.post9203747254730170117..comments2023-08-08T00:53:58.434-07:00Comments on Garth Kroeker: Antidepressant Combinations for Resistant DepressionGKhttp://www.blogger.com/profile/14714377295981745087noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-6886575137375451769.post-905372774893738792010-12-17T10:16:02.331-08:002010-12-17T10:16:02.331-08:00Hello,
I can't give extremely specific person...Hello,<br /><br />I can't give extremely specific personal medical advice on a blog, but I can comment in general:<br /><br />A seroquel + zoloft + mirtazapine combination is not contraindicated. As with any therapeutic trial, it would be important to weigh possible positives and negatives:<br />1) Positives: could improve depressive symptoms. Might reduce SSRI-induced side effects or reduce need for as high a dose of SSRI.<br />2) Negatives: could provoke mood cycling; more side effects such as sedation, weight gain, or rare but more immediately serious side effects such as liver problems, severe agitation, etc. Would cost more money. Does not have an extremely clear evidence base in research, as yet, aside, perhaps, from individual case studies.<br /><br />There may be more items in both the positive and negative column, that could be specific to individual situations or histories. Finally, it would be up to the individual and caregivers to weigh these factors and decide one way or another.<br /><br />Best wishes,<br />GKGKhttps://www.blogger.com/profile/14714377295981745087noreply@blogger.comtag:blogger.com,1999:blog-6886575137375451769.post-20005160275212866272010-12-17T08:52:53.883-08:002010-12-17T08:52:53.883-08:00My Dr is pretty much someone who prescribes Seroqu...My Dr is pretty much someone who prescribes Seroquel 300 mg XR to all his bipolar patients. He actually told me this, not as bluntly, but still. Also, as a rule he is against prescribing more than one medication per patient.<br /><br />As you know, not many people with difficult to treat bipolar disorder are to be helped by that kind of general solution. <br /><br />I'm on Seroquel and Zoloft. My biggest fear is that Zoloft will stop being effective as it has many times before. <br /><br />When/if that happens, could Mirtazapine as an add-on be an idea worth trying in your opinion? Or is a combination of Seroquel+Zoloft+Mirtazapine impossible? I take Seroquel before I go to sleep and Zoloft in the morning.<br /><br />I'm bipolar 2 and chronic depression is my biggest problem. The manic side is not an issue anymore thanks to Seroquel.<br /><br />An answer would be much appreciated!<br /><br />Kind regards<br />/Elin, SwedenAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6886575137375451769.post-54215225844285068552009-05-27T11:49:32.425-07:002009-05-27T11:49:32.425-07:00Resistant depression is extremely tenacious and de...Resistant depression is extremely tenacious and debilitating, and I think we have to keep an open mind about exploring options including drug combinations. <br /><br />We need more unbiased research data, looking at larger numbers of patients for longer periods of time, to help guide treatment decisions better. <br /><br />Meanwhile, the existing evidence--limited as it is--does not discourage careful trials of combinations, provided patients are followed very closely for interactions and side-effects.GKhttps://www.blogger.com/profile/14714377295981745087noreply@blogger.comtag:blogger.com,1999:blog-6886575137375451769.post-59875651967208176702009-05-27T10:05:37.747-07:002009-05-27T10:05:37.747-07:00Nice overview, overall not much evidence that comb...Nice overview, overall not much evidence that combinations can be more efficacious. The danger of interactions and side-effects increases with more psychopharmacological drugs.<br />Kind regards Dr ShockDr Shockhttp://www.shockmd.comnoreply@blogger.com